HLA B5 has two splits B*51 and B*52 of which only B*51 is important in the etiology of Behcets disease. HLA B* 51 and B*52 have almost similar distribution in Indian population ranging from 6.8- 15% in various ethnic groups in the country. Ocular involvement, which could lead to serious complications, is a very important feature of Behcets disease. HLA- B *51 positivity increases the risk for Behcets disease by six times. HLA B*52 is not associated with additional risk.