Ibs-smart® results interpretation guide

Anti-CdtB Anti-Vinculin Test Result Clinical Association
Elevated Not Elevated Positive
  • Suggests recent or past gastroenteritis.
  • Immune system has responded to CdtB toxin with antibodies.

Studies show that anti-CdtB predicts a disturbed microbiome has occurred after gastroenteritis.

Not Elevated Elevated Positive
  • Initial gastroenteritis may have occurred a long time ago.
  • Anti-vinculin, an autoimmune response, has developed and altered microbiome may be seen.

Based on published data, it is believed that having elevated anti-vinculin levels indicate a more severe condition and a greater chronicity of disease. (Anti-vinculin autoimmunity usually develops 3-4 months after the infection.) Furthermore, there is data to suggest that the patient is at higher risk for subsequent infectious enteritis.

Elevated Elevated Positive
  • Immune response is fighting toxin with antibodies and fueling increasing Anti-vinculin.
  • Anti-vinculin autoimmune response has developed and an altered microbiome may be seen.

This profile suggests a recent infection or an infection in the more distant past. Based on published data, it is believed that having elevated anti-vinculin levels indicate a more severe condition and a greater chronicity of disease. Furthermore, there is data to suggest that the patient is at higher risk for subsequent infectious enteritis.

Not Elevated Not Elevated Inconclusive
  • Patient could still have IBS, but it may not be post-infectious in nature.
  • Additional testing may help determine another cause for symptoms.