Specimen consists of biopsy fragments of while matter with a moderately atypical infiltrate of astrocytic cells. there is no evidence of vascular proliferation or necrosis. Scattered mitosis is seen.
Although histologic grade is that of a grade II astrocytoma the positivity for H3K27 M is consistent with a diagnosis of a diffuse midline glioma, H3K27 M mutant which are considered as grade IV lesions due to their historically aggressive clinical behaviour.
Correlation with radiology findings is recommended to confirm midline location of the tumor
GFAP : Diffuse positive
IDH : Negative (R132 H IHC),
ATRX : Lost
P53: Negative(wild type),
H3K27 M : Positive(consistent with mutant)
Ki67 5 -7%,
H&E
P53 (BP 53-12)
GFAP (Polyclonal)
ATRX (D-5)
H3K27 M.
Ki67 (MIB-1)
IDH-1 (R132 H)
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*Our customer care team will reach out to you for scheduling the sample collection at the defined intervals
*The Diagnostic Monitoring Tests will be done once the Free Trial Period is over
*Our customer care team will reach out to you for scheduling the sample collection at the defined intervals